Designing systems that replace coordination with execution

Every PGx report you release starts aging the moment it is signed out. CPIC guidance is revised, FDA and DailyMed labels add or change interactions, and the patient picks up a new prescription — yet the report on file still reflects the science of its issue date. Nobody has time to re-read every historical case against every change, so actionable shifts slip past unnoticed.

SignalPGx keeps every report alive, continuously re-analyzing prior results against new evidence and surfacing exactly what a medical director needs to review.

When a guideline, drug label, or a patient's medication list changes, SignalAI re-scores the affected historical genotypes and compares the new interpretation against what was previously reported. Only genuine, clinically meaningful deltas are raised — a new phenotype-drug flag, an escalated risk level, a fresh gene-drug interaction — and each one is routed to your medical director as a review item, never auto-published. The clinician decides whether to reissue; the platform never changes guidance on its own.

Living Reanalysis continuously watches the inputs that make a report go stale and turns each change into a reviewable action:

• Guideline and evidence updates

• Drug-label and interaction changes

• New or discontinued patient medications

• Director-reviewed reissue and alerts

Reanalysis runs against versioned evidence, so every flag carries its provenance — which guideline revision or label change triggered it, and how the interpretation moved. The same deterministic scoring logic that produced the original report re-runs the update, so results stay consistent across cases and reviewers rather than drifting with whoever happens to look. Nothing reaches a patient chart until a qualified clinician signs it.

The review queue lives inside the workflow your team already uses — the same sign-out and audit trail as first-time reports, scoped to each lab under strict tenant isolation. Reissued reports flow back out through your existing delivery channels and EHR integrations, and every reanalysis event is captured in the audit log as a HIPAA business associate. No parallel system, no separate inbox to babysit.

As your reported volume grows into the tens of thousands, the value compounds: a single CPIC or label change can be evaluated against your entire historical catalog in one pass, replacing an impossible manual re-review with a short, triaged worklist. Directors spend their time on the handful of cases that actually moved, not on scanning archives for the ones that might have.

Your lab delivers guidance that stays current for the life of the patient, and clinicians can trust that a report on file still reflects the best available evidence — with a documented, clinician-owned trail behind every update.