
Delivery Surfaces
FHIR Resources
Coding Standards
AI Workflow
EHR + CDS Integrations
We deliver each lab's pharmacogenomic interpretations directly into the EHR through HL7 FHIR, SMART on FHIR launch, and CDS Hooks, so prescribers see reviewed gene-drug guidance inside their existing ordering workflow instead of a separate portal, with coded results mapped to LOINC, HGNC, and RxNorm. Every recommendation remains reviewed and owned by a licensed clinician.
Year
2026
Industry
EHR Interoperability & Clinical Decision Support
SERVICE USED
Evidence Interpretation, Report Automation
Challenge
Pharmacogenomic results stranded in a separate portal rarely reach the prescriber at the moment of ordering.
(spx® — the problem)
Even well-reviewed PGx interpretations lose their value when they live in a standalone portal disconnected from the EHR: prescribers must leave their workflow to find them, guidance is missed at the point of ordering, and structured, coded results never make it into the chart. Without HL7 FHIR, SMART on FHIR, and CDS Hooks integration, gene-drug guidance arrives too late and in the wrong place to inform the prescribing decision.

Play
Operational Overview
1:42 min overview
(spx® — solution)
Designing systems that replace coordination with execution
PGx results that live in a PDF portal never reach the moment they matter — the point of prescribing. Clinicians re-key genotypes, hunt through faxed reports, and act on stale information, while your lab absorbs the support calls that follow. The value your assay creates evaporates in the gap between result and order.
SignalPGx delivers physician-reviewed pharmacogenomic guidance straight into the EHR, at the moment a drug is ordered.
We speak the interfaces your health-system partners already run — FHIR R4, HL7 ORU, and CDS Hooks — so branded reports post as discrete, structured results and alerts surface during order entry. Every alert is grounded in an interpretation your medical director signed out; SignalAI drafts and scores the guidance, but a qualified clinician reviews and owns each release before it ever crosses the interface.
Integration spans the full clinical path:
FHIR R4 structured result delivery
HL7 ORU report messaging
CDS Hooks point-of-prescribing alerts
Branded, physician-reviewed report payloads
Alerts stay reliable because they carry the same signed-out interpretation the report does — coded to HGNC, RxNorm, and LOINC so meaning survives the trip between systems. When a report is rescored against a moved guideline, the interface delivery updates in lockstep, so no clinician ever prescribes against a stale card.
Nothing about your accessioning or sign-out workflow changes. Results flow from your existing LIS through SignalPGx and into the ordering provider's chart on the transport their EHR already expects — Epic, Cerner, or any FHIR- and HL7-conformant system — with per-tenant credentials and a full audit trail on every message.
As volume grows, integration is what keeps support cost flat. Structured, coded delivery ends manual re-entry and the interpretation questions that clog your phones, while point-of-prescribing alerts turn each report into a demonstrable clinical touchpoint your health-system accounts can measure and defend at renewal.
Your lab becomes the pharmacogenomics layer inside the EHR — not a PDF at the end of it — and clinicians get reviewed, actionable guidance exactly when they write the prescription.

(spx® — Technology Stacks)
SMART
CDS
LOINC
FHIR
HGNC
(spx® — from the team)
The interpretation reaches the prescriber inside the chart, at the moment of ordering.

Adam Vale
Chief Technology Officer, SignalPGx

Delivery Surfaces
FHIR Resources
Coding Standards
AI Workflow
EHR + CDS Integrations
We deliver each lab's pharmacogenomic interpretations directly into the EHR through HL7 FHIR, SMART on FHIR launch, and CDS Hooks, so prescribers see reviewed gene-drug guidance inside their existing ordering workflow instead of a separate portal, with coded results mapped to LOINC, HGNC, and RxNorm. Every recommendation remains reviewed and owned by a licensed clinician.
Year
2026
Industry
EHR Interoperability & Clinical Decision Support
SERVICE USED
Evidence Interpretation, Report Automation
Challenge
Pharmacogenomic results stranded in a separate portal rarely reach the prescriber at the moment of ordering.
(spx® — the problem)
Even well-reviewed PGx interpretations lose their value when they live in a standalone portal disconnected from the EHR: prescribers must leave their workflow to find them, guidance is missed at the point of ordering, and structured, coded results never make it into the chart. Without HL7 FHIR, SMART on FHIR, and CDS Hooks integration, gene-drug guidance arrives too late and in the wrong place to inform the prescribing decision.

Play
Operational Overview
1:42 min overview
(spx® — solution)
Designing systems that replace coordination with execution
PGx results that live in a PDF portal never reach the moment they matter — the point of prescribing. Clinicians re-key genotypes, hunt through faxed reports, and act on stale information, while your lab absorbs the support calls that follow. The value your assay creates evaporates in the gap between result and order.
SignalPGx delivers physician-reviewed pharmacogenomic guidance straight into the EHR, at the moment a drug is ordered.
We speak the interfaces your health-system partners already run — FHIR R4, HL7 ORU, and CDS Hooks — so branded reports post as discrete, structured results and alerts surface during order entry. Every alert is grounded in an interpretation your medical director signed out; SignalAI drafts and scores the guidance, but a qualified clinician reviews and owns each release before it ever crosses the interface.
Integration spans the full clinical path:
FHIR R4 structured result delivery
HL7 ORU report messaging
CDS Hooks point-of-prescribing alerts
Branded, physician-reviewed report payloads
Alerts stay reliable because they carry the same signed-out interpretation the report does — coded to HGNC, RxNorm, and LOINC so meaning survives the trip between systems. When a report is rescored against a moved guideline, the interface delivery updates in lockstep, so no clinician ever prescribes against a stale card.
Nothing about your accessioning or sign-out workflow changes. Results flow from your existing LIS through SignalPGx and into the ordering provider's chart on the transport their EHR already expects — Epic, Cerner, or any FHIR- and HL7-conformant system — with per-tenant credentials and a full audit trail on every message.
As volume grows, integration is what keeps support cost flat. Structured, coded delivery ends manual re-entry and the interpretation questions that clog your phones, while point-of-prescribing alerts turn each report into a demonstrable clinical touchpoint your health-system accounts can measure and defend at renewal.
Your lab becomes the pharmacogenomics layer inside the EHR — not a PDF at the end of it — and clinicians get reviewed, actionable guidance exactly when they write the prescription.

(spx® — Technology Stacks)
SMART
CDS
LOINC
FHIR
HGNC
(spx® — from the team)
The interpretation reaches the prescriber inside the chart, at the moment of ordering.

Adam Vale
Chief Technology Officer, SignalPGx

Delivery Surfaces
FHIR Resources
AI Workflow
EHR + CDS Integrations
We deliver each lab's pharmacogenomic interpretations directly into the EHR through HL7 FHIR, SMART on FHIR launch, and CDS Hooks, so prescribers see reviewed gene-drug guidance inside their existing ordering workflow instead of a separate portal, with coded results mapped to LOINC, HGNC, and RxNorm. Every recommendation remains reviewed and owned by a licensed clinician.
Year
2026
Industry
EHR Interoperability & Clinical Decision Support
SERVICE USED
Evidence Interpretation, Report Automation
Challenge
Pharmacogenomic results stranded in a separate portal rarely reach the prescriber at the moment of ordering.
(spx® — the problem)
Even well-reviewed PGx interpretations lose their value when they live in a standalone portal disconnected from the EHR: prescribers must leave their workflow to find them, guidance is missed at the point of ordering, and structured, coded results never make it into the chart. Without HL7 FHIR, SMART on FHIR, and CDS Hooks integration, gene-drug guidance arrives too late and in the wrong place to inform the prescribing decision.

Play
Operational Overview
1:42 min overview
(spx® — solution)
Designing systems that replace coordination with execution
PGx results that live in a PDF portal never reach the moment they matter — the point of prescribing. Clinicians re-key genotypes, hunt through faxed reports, and act on stale information, while your lab absorbs the support calls that follow. The value your assay creates evaporates in the gap between result and order.
SignalPGx delivers physician-reviewed pharmacogenomic guidance straight into the EHR, at the moment a drug is ordered.
We speak the interfaces your health-system partners already run — FHIR R4, HL7 ORU, and CDS Hooks — so branded reports post as discrete, structured results and alerts surface during order entry. Every alert is grounded in an interpretation your medical director signed out; SignalAI drafts and scores the guidance, but a qualified clinician reviews and owns each release before it ever crosses the interface.
Integration spans the full clinical path:
FHIR R4 structured result delivery
HL7 ORU report messaging
CDS Hooks point-of-prescribing alerts
Branded, physician-reviewed report payloads
Alerts stay reliable because they carry the same signed-out interpretation the report does — coded to HGNC, RxNorm, and LOINC so meaning survives the trip between systems. When a report is rescored against a moved guideline, the interface delivery updates in lockstep, so no clinician ever prescribes against a stale card.
Nothing about your accessioning or sign-out workflow changes. Results flow from your existing LIS through SignalPGx and into the ordering provider's chart on the transport their EHR already expects — Epic, Cerner, or any FHIR- and HL7-conformant system — with per-tenant credentials and a full audit trail on every message.
As volume grows, integration is what keeps support cost flat. Structured, coded delivery ends manual re-entry and the interpretation questions that clog your phones, while point-of-prescribing alerts turn each report into a demonstrable clinical touchpoint your health-system accounts can measure and defend at renewal.
Your lab becomes the pharmacogenomics layer inside the EHR — not a PDF at the end of it — and clinicians get reviewed, actionable guidance exactly when they write the prescription.

(spx® — Technology Stacks)
SMART
CDS
LOINC
FHIR
HGNC
(spx® — from the team)
The interpretation reaches the prescriber inside the chart, at the moment of ordering.

Adam Vale
Chief Technology Officer, SignalPGx

Delivery Surfaces
FHIR Resources
Coding Standards
AI Workflow
EHR + CDS Integrations
We deliver each lab's pharmacogenomic interpretations directly into the EHR through HL7 FHIR, SMART on FHIR launch, and CDS Hooks, so prescribers see reviewed gene-drug guidance inside their existing ordering workflow instead of a separate portal, with coded results mapped to LOINC, HGNC, and RxNorm. Every recommendation remains reviewed and owned by a licensed clinician.
Year
2026
Industry
EHR Interoperability & Clinical Decision Support
SERVICE USED
Evidence Interpretation, Report Automation
Challenge
Pharmacogenomic results stranded in a separate portal rarely reach the prescriber at the moment of ordering.
(spx® — the problem)
Even well-reviewed PGx interpretations lose their value when they live in a standalone portal disconnected from the EHR: prescribers must leave their workflow to find them, guidance is missed at the point of ordering, and structured, coded results never make it into the chart. Without HL7 FHIR, SMART on FHIR, and CDS Hooks integration, gene-drug guidance arrives too late and in the wrong place to inform the prescribing decision.

Play
Operational Overview
1:42 min overview
(spx® — solution)
Designing systems that replace coordination with execution
PGx results that live in a PDF portal never reach the moment they matter — the point of prescribing. Clinicians re-key genotypes, hunt through faxed reports, and act on stale information, while your lab absorbs the support calls that follow. The value your assay creates evaporates in the gap between result and order.
SignalPGx delivers physician-reviewed pharmacogenomic guidance straight into the EHR, at the moment a drug is ordered.
We speak the interfaces your health-system partners already run — FHIR R4, HL7 ORU, and CDS Hooks — so branded reports post as discrete, structured results and alerts surface during order entry. Every alert is grounded in an interpretation your medical director signed out; SignalAI drafts and scores the guidance, but a qualified clinician reviews and owns each release before it ever crosses the interface.
Integration spans the full clinical path:
FHIR R4 structured result delivery
HL7 ORU report messaging
CDS Hooks point-of-prescribing alerts
Branded, physician-reviewed report payloads
Alerts stay reliable because they carry the same signed-out interpretation the report does — coded to HGNC, RxNorm, and LOINC so meaning survives the trip between systems. When a report is rescored against a moved guideline, the interface delivery updates in lockstep, so no clinician ever prescribes against a stale card.
Nothing about your accessioning or sign-out workflow changes. Results flow from your existing LIS through SignalPGx and into the ordering provider's chart on the transport their EHR already expects — Epic, Cerner, or any FHIR- and HL7-conformant system — with per-tenant credentials and a full audit trail on every message.
As volume grows, integration is what keeps support cost flat. Structured, coded delivery ends manual re-entry and the interpretation questions that clog your phones, while point-of-prescribing alerts turn each report into a demonstrable clinical touchpoint your health-system accounts can measure and defend at renewal.
Your lab becomes the pharmacogenomics layer inside the EHR — not a PDF at the end of it — and clinicians get reviewed, actionable guidance exactly when they write the prescription.

(spx® — Technology Stacks)
SMART
CDS
LOINC
FHIR
HGNC
(spx® — from the team)
The interpretation reaches the prescriber inside the chart, at the moment of ordering.

Adam Vale
Chief Technology Officer, SignalPGx
(spx® — 05)
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(spx® — 15)
OUR PRINCIPLES
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We turn genotyping results into
living, evidence-graded PGx reports.
We’ll review your
workflows, identify
where AI can create
impact, and outline
a clear path forward.
We’ll review your reporting workflow, map your evidence sources, and outline a clear path to launch PGx.
We’ll review your workflows, identify where AI can create impact, and outline
a clear path forward.
No preparation needed — we’ll guide the conversation
and focus on what matters.
No preparation needed — we’ll guide the conversation and focus on what matters.




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