Why a static report goes out of date

In most reporting workflows, a report is generated once and then frozen. The genotype was correct on the day it was signed, but the interpretation layered on top of it reflects only what was known at that moment. When a guideline moves or a new gene-drug interaction is recognized, older reports silently drift away from best practice while everyone assumes they are still accurate.

SignalPGx treats each report as a living record. Genotype calls stay fixed, but the evidence-graded interpretation is re-evaluated whenever the inputs that shaped it change. Instead of relying on someone to remember to revisit an old result, the platform continuously watches for the conditions that would alter guidance.

Re-analysis when guidelines change

Pharmacogenomic evidence is a moving target. SignalPGx grades interpretations against CPIC guidelines, FDA pharmacogenomic biomarker labeling, DailyMed prescribing data, and DPWG, reconciled from more than fifteen curated sources across fifty pharmacogenes and roughly 950 medications.

When any of that source evidence is updated, Living Reports re-score the affected reports so their guidance stays:

• current

• consistent

• auditable

This removes the dependency on manual review cycles and keeps guidance reliable across every report the lab has ever released.

Re-analysis when medications change

A genotype only matters in the context of the drugs a patient is actually taking. As new prescriptions are added, a variant that was previously silent can become clinically relevant to the therapy in front of the prescriber.

Living Reports re-analyze against the updated medication list, surfacing gene-drug interactions that were not applicable before. A report written when a patient took two medications can automatically flag a concern when a third is introduced, closing the gap between a fixed genotype and an evolving therapy.

The medical director stays in control

Automatic re-analysis never changes what a patient sees on its own. SignalAI assists interpretation and flags gene-drug interactions, but it never signs out a result by itself.

When Living Reports detect that guidance has shifted, the affected report is flagged for a fresh review rather than quietly rewritten. The lab's medical director examines the change and signs out the updated report, so a licensed clinician remains accountable for every conclusion delivered into the EHR.

Delivered into the workflows labs already use

Keeping reports current only helps if the updates reach the point of care. SignalPGx delivers through the channels clinical teams already rely on rather than adding another portal to check.

Updated reports flow back through the same delivery paths as the original.

FHIR R4, HL7 ORU, CDS Hooks, and SMART on FHIR carry refreshed guidance into the EHR, while a Patient Passport gives patients a revocable QR link to a minimal-PHI view they can share and the lab can revoke.

decision = model.predict(input_data)
execute(decision)

A clear, auditable trail

Because every re-analysis is recorded, labs can see exactly why a report changed and when. On secured AWS infrastructure with encryption in transit and at rest, role-based access control, strict tenant isolation, and a full audit trail, each update becomes observable rather than mysterious.

This gives the lab a defensible record of:

1. what evidence changed

2. which reports were affected

3. who reviewed the update

Instead of hoping older results still hold up, the lab can demonstrate that its guidance reflects the current standard of care.

Conclusion

A PGx report should not decay the moment it is signed; it should keep pace with the evidence and the patient.

Living Reports let white-label labs deliver pharmacogenomic guidance that stays current, keep a physician accountable for every change, and give prescribers confidence that what they are reading reflects today's science, not last year's. SignalPGx is not a diagnostic test and does not replace the physician; final prescribing decisions always remain with the ordering clinician.